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周曉明 博士

時間:2018-10-29瀏覽:845設(shè)置

周曉明 博士

研究方向

主要研究領(lǐng)域?yàn)楦杏X神經(jīng)生物學(xué)。采用分子神經(jīng)生物學(xué)、神經(jīng)電生理學(xué)及行為學(xué)等技術(shù)和方法,以聽覺系統(tǒng)為模型研究腦感覺信息處理機(jī)制、多通道感覺信息整合及功能可塑性、可塑性和行為的關(guān)系以及感覺損傷的修復(fù)及功能代償?shù)?。研究獲上海市青年科技啟明星計劃、啟明星(跟蹤)計劃、浦江人才計劃、上海市基礎(chǔ)研究重點(diǎn)項目、教育部新世紀(jì)優(yōu)秀人才計劃及自然科學(xué)基金等資助。已發(fā)表研究論文45篇(其中作為第一或通訊作者的有2篇Nature子刊,4篇PNAS,3篇J Neurosci,1篇Cereb Cortex,2篇J Neurophysiol)并授權(quán)2項專利。“中樞聽覺可塑性及其機(jī)制”獲2014年教育部高等學(xué)??茖W(xué)技術(shù)獎(自然科學(xué)獎)二等獎(排名第一)。


社會兼職

上海市生理學(xué)會理事

美國神經(jīng)科學(xué)學(xué)會會員

美國耳鼻咽喉科研究協(xié)會會員

國際神經(jīng)行為學(xué)會會員



學(xué)術(shù)成果

Selected publications:

1. Zhu X, Liu X, Wei F, Wang F, Merzenich MM, Schreiner CE, Sun X, Zhou X (2016) Perceptual training restores impaired cortical temporal processing due to lead exposure. Cereb Cortex 26:334-345 (Corresponding author)

2. Zhou X, Lu YF, Darling RD, Simpson KL, Zhu X, Wang F, Yu L, Sun X, Merzenich MM, Lin RC (2015) Behavioral training reverses global cortical network dysfunction induced by perinatal antidepressant exposure. Proc Natl Acad Sci USA 112:2233-2238 (Co-corresponding author)


3. Zhu X, Wang F, Hu H, Sun X, Kilgard MP, Merzenich MM, Zhou X (2014) Environmental acoustic enrichment promotes recovery from developmentally degraded auditory cortical processing. J Neurosci 34:5406-5415 (Corresponding author)

4. Zhang Y, Zhao Y, Zhu X, Sun X, Zhou X (2013) Refining cortical representation of sound azimuths by auditory discrimination training.J Neurosci 33:9693-9698 (Corresponding author)

5. Zhou X, Merzenich MM (2012) Environmental noise exposure degrades normal listening processes. Nat Commun10.1038/ncomms1849, 3:843 (Corresponding author)

6. Guo F, Zhang J, Zhu X, Cai R, Zhou X, Sun X (2012) Auditory discrimination training rescues developmentally degraded directional selectivity and restores mature expression of GABAA and AMPA receptor subunits in rat auditory cortex. Behav Brain Res 229:301-307 (Co-corresponding author)

7. Zhou X, Panizzutti R, de Villers-Sidani é, Madeira C, Merzenich MM (2011) Natural restoration of critical period plasticity in the juvenile and adult primary auditory cortex. J Neurosci 31:5625-5634 (Corresponding author)

8. Pan Y, Zhang J, Cai R, Zhou X, Sun X (2011) Developmentally degraded directional selectivity of the auditory cortex can be restored by auditory discrimination training in adults. Behav Brain Res 225:596-602 (Co-corresponding author)

9. Zhou X, de Villers-Sidani é, Panizzutti R, Merzenich MM (2010) Successive-signal biasing for a learned sound sequence. Proc Natl Acad Sci USA 107:14839-14844 (Co-corresponding author)

10. Cai R, Zhou X, Guo F, Xu J, Zhang J, Sun X (2010) Maintenance of enriched environment-induced changes of auditory spatial sensitivity and expression of GABA(A), NMDA, and AMPA receptor subunits in rat auditory cortex. Neurobiol Learn Mem 94:452-460

11. de Villers-Sidani é, Alzghoul L, Zhou X, Simpson KL, Lin RCS, Merzenich MM (2010) Recovery of age-related changes in the rat primary auditory cortex with operant training. Proc Natl Acad Sci USA 107:13900-13905

12. Zhou X, Merzenich MM (2009) Developmentally degraded cortical temporal processing restored by training. Nat Neurosci 12:26-28 (Corresponding author)

13. Zhou X, Merzenich MM (2008) Enduring effects of early structured noise exposure on temporal modulation in the primary auditory cortex. Proc Natl Acad Sci USA 105:4423-4428 (Co-corresponding author)

14. Zhou X, Nagarajan N, Mossop BJ, Merzenich MM (2008) Influences of un-modulated acoustic inputs on functional maturation and critical-period plasticity of the primary auditory cortex. Neuroscience 154:390-396

15. Zhou X, Merzenich MM (2007) Intensive training in adults refines A1 representations degraded in an early postnatal critical period.Proc Natl Acad Sci USA 104:15935-15940

16. Zhou X, Jen PH (2007) Corticofugal modulation of multi-parametric auditory selectivity in the midbrain of the big brown bat. J Neurophysiol 98:2509-2516 (Corresponding author)

17. Zhou X, Jen PHS (2005) Corticofugal modulation of directional sensitivity in the midbrain of the big brown bat, Eptesicus fuscus,Hear Res 203:201-215

18. Jen PHS, Zhou X (2003) Corticofugal modulation of amplitude domain processing in the midbrain of the big brown bat, Eptesicus fuscusHear Res 184:91-106

19. Zhou X, Jen PHS (2002) The role of GABAergic inhibition in shaping directional selectivity of bat inferior collicular neurons determined with temporally patterned pulse trains, J Comp Physiol 188:815-826

20. Jen PHS, Zhou X, Zhang JP, Chen QC, Sun XD (2002) Brief and short-term corticofugal modulation of acoustic signal processing in the bat midbrain, Hear Res 168:196-207

21. Zhou X, Jen PHS (2002) The effect of sound duration on rate-intensity functions of inferior collicular neurons in the big brown bat,Eptesicus fuscusHear Res 166:124-135

22. Jen PHS, Zhou X, Wu CH (2001) Temporally patterned sound pulse trains affect intensity and frequency sensitivity of inferior collicular neurons of the big brown bat, Eptesicus fuscusJ Comp Physiol 187:605-616

23. Zhou X, Jen PHS (2001) The effect of sound intensity on duration tuning characteristics of bat inferior collicular neurons, J Comp Physiol 187:63-73

24. Zhou X, Jen PHS (2000) Brief and short-term corticofugal modulation of subcortical auditory responses in the big brown bat,Eptesicus fuscusJ Neurophysiol 84:3083-3087

25. Zhou X, Jen PHS (2000) Neural inhibition sharps spatial selectivity of bat inferior collicular neurons, J Comp Physiol 186:389-398

26. Jen PHS, Zhou X (1999) Temporally patterned sound trains affect duration tuning characteristics of bat inferior collicular neurons,J Comp Physiol 185:471-478


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